“Apparently, someone accidentally washed his shirt in holy water,” joked Che of the red patch of skin seen around Trump’s collar at a Medal of Honor ceremony.

The quip sparked a wave of laughter and applause from the “SNL” crowd, which lasted just over 10 seconds.

The White House told HuffPost the rash was due to “preventative skin treatment,” noting that the president was using a “very common cream” on his neck for one week and the redness is expected to “last for a few weeks.”

Earlier in the “SNL” news segment, host Colin Jost questioned why Trump would fire his head of Homeland Security, Kristi Noem.

“Wait. What? Why? I mean, name one to 20 things she did wrong,” he cracked.

He proceeded to list several controversies tied to Noem, including her description of Minneapolis residents shot and killed by federal immigration agents — Renee Good and Alex Pretti — as “domestic terrorists.”

“Was it spending $220 million of taxpayer money on an ad campaign where she dressed up as Jessie from ‘Toy Story’?” asked Jost of Noem’s horseback ad in front of Mount Rushmore.

He used the ad to make a dig at Noem over her alleged affair with one of her aides, “She’s so happy riding the horse in this, I bet his name is Corey Lewandowski.”

Jost admitted that “on some level,” he feels bad for Noem.

“Imagine being singled out as the worst member of Trump’s cabinet. That’s like someone coming up to you at a party and saying, ‘We think you should leave, you’re making Diddy uncomfortable,’” he quipped.

Watch more from “Weekend Update” in the clips below.