In a video backed by a mellow piano instrumental, the first lady is seen strolling past several Christmas trees that are wrapped in white lights before taking a closer look at a white ornament.

“That is so sad. They didn’t even play a Christmas carol; they played the before-music from an anti-depressant commercial,” Colbert quipped before playing the track again and launching into an impression of a drug ad narrator. “Ask your doctor if Somazome is right for you. Side effects of Somazome include silent wandering.”

“Truly, truly historic because it’s the first Legos you kind of want to step on,” Colbert joked.

Watch more of Colbert’s Wednesday monologue on “The Late Show.”